The cumulative probability of developing the disease before 85 years of age was 2.8% in 2002. It accounted for 5.8% of all cancers incidents among Swedish women in 2002. Another hormone dependent cancer is endometrial cancer. The study gave support to the hypothesis that exposure to endocrine disruptors during the fetal period may be of etiologic importance in the etiology of testicular cancer.
Similar concentrations were found in cases with testicular cancer as in the population controls. In a case-control study on patients with testicular cancer we found higher concentrations of PCBs, HCB and chlordanes in mothers to cases than in mothers to controls. Also p,p'-dichlorodiphenyl-dichloroethylene (p,p'-DDE) the most persistent metabolite of p,p'-DDT has been postulated to be an environmental endocrine disruptor. Hexachlorobenzene ( HCB) has been shown to have endocrine-disrupting properties. PCBs have been shown to reverse gonadal sex in turtle5 and abnormalities of reproductive development has been described in juvenile alligators living in contaminated environment in Florida. Some persistent organic pollutants (POPs) such as polychlorinated biphenyls (PCBs), and especially the hydroxylated metabolites, and chlordanes, have been postulated to be endocrine disruptors. In humans concern has been focused on ''endocrine disrupting chemicals'' with either estrogenic or antiestrogenic activities. Impacts of increasing levels of xenoestrogens have been observed in aquatic organisms.
Hospital, Oerebro (Sweden)Įnvironmental pollutants with hormonal activity, such as xenoestrogens, have for several years been of concern as potential risk factors for hormone dependant tumors.
[MTM Research Centre, Oerebro Univ., Oerebro (Sweden) Hardell, L. Adipose tissue concentrations of PCB, HCB, chlordane, PBDE and P,P'-DDE and the risk for endometrial cancerĮnergy Technology Data Exchange (ETDEWEB)
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